• Flatiron Health UK Emma Salib (chair)

• Nada Boualam (subject matter expert)

• Sam Eiffert (subject matter expert)

• Jennifer McCaffery (lay), Hayley Hall (lay)

• Sonia Patton (patient)

• Thomas Smith (patient)

• Yanrong Jiang (clinical)

No conflicts declared by panel

Approved

• The lay summary provided an excellent overview of both colorectal cancer and prostate cancer and clearly explained the impact of these cancers on the lives of patients.

• The different types and stages of prostate cancer were clearly outlined: e.g. mCSPSC, mCRPC

• Strong study rationale and the outlined scope of the data request was clear

• The application is for a Services Project Data Access Request and as such, Flatiron will be accessing the data on their behalf. Amgen will not themselves have access to the data (only the aggregated analytical outputs). If Amgen deem the data ‘fit for purpose’ in the future more effective and targeted treatment options could be investigated.

• The panel raised several comments on other aspects of the application, including:
  
  

  • More information on the different types of bowel cancers

  • Additional details on the specific analysis that will be carried out.

  • Further clarity on the dissemination of necessary information to patients in the future.

  • Further context on how the outputs of this work will be used in the future.